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Updated: Jan 25, 2026

In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
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適応 的 な 免疫 抵抗 は 腫瘍 を 引き起こす 幹 細胞 から 生じ ます

Yuxuan Miao1, Hanseul Yang1, John Levorse1

  • 1Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Cell
|April 30, 2019
PubMed
まとめ

腫瘍を誘発する幹細胞 (tSCs) は,T細胞を抑制するCD80を発現することによって,免疫療法に抵抗します. この相互作用を阻害したり,TGF-βを標的にしたりすると,がん免疫療法後の腫瘍の再発が減少します.

キーワード:
アドプティブT細胞移植療法免疫回避免疫幹細胞の相互作用系統追跡単細胞RNAシーケンシング状細胞がん腫瘍幹細胞

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