関連する実験動画

Updated: Jul 13, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

タイロシンリン酸化は,pp60c-srcの生化学的および生物学的性質を調節する

H Piwnica-Worms, K B Saunders, T M Roberts

    Cell
    |April 10, 1987
    PubMed
    まとめ

    pp60c-srcにおけるチロシンリン酸化を調査すると,Tyr 527における低リン酸化とTyr 416における高リン酸化が,その完全な変換の可能性にとって極めて重要であることが明らかになる.

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    関連する概念動画

    Phosphorylation01:02

    Phosphorylation

    The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
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    Phosphorylation01:02

    Phosphorylation

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    During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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    Protein Kinases and Phosphatases

    Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
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    Covalently Linked Protein Regulators

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    Amplifying Signals via Enzymatic Cascade

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    Receptor Tyrosine Kinases

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