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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow08:58

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This protocol provides a method for the systematic global optimization of genetically encoded biosensors through automation-assisted genetic library generation and assessment. This is coupled with design-of-experiment methodologies to streamline experimentation and enable the selection of genetic components to tune biosensors to specific design outcomes.
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Access to decentralized, low-cost, and high-capacity diagnostics that can be deployed into the community for decentralized testing is critical for combating global health crises. This manuscript describes how to build paper-based diagnostics for viral RNA sequences that can be detected with a portable optical...
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Field-effect biosensing (FEB) is a label-free technique for detecting biomolecular interactions. It measures the electric current through the graphene biosensor to which the binding targets are immobilized. The FEB technology was used to evaluate biomolecular interactions between Hsp90 and Cdc37 and a strong interaction between the two proteins was...
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関連する実験動画

Updated: Jan 6, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

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高温の散発金属ガラス

Ming-Xing Li1,2, Shao-Fan Zhao3, Zhen Lu4

  • 1Institute of Physics, Chinese Academy of Sciences, Beijing, China.

Nature
|May 3, 2019
PubMed
まとめ
この要約は機械生成です。

研究者らは,高温のガラス化と広範囲の超冷却液体領域を持つ新しいイリジウム/ニッケル/タンタール金属ガラスを開発した. これらの先進的な金属ガラスは,高温の強度と高要求の用途のための形状性を提供します.

さらに関連する動画

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関連する実験動画

Last Updated: Jan 6, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

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Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics
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Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

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Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

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科学分野:

  • 材料科学
  • 金属工学
  • 固体物理学

背景:

  • 金属ガラスは,従来の合金と比較して優れた機械的性質を提供します.
  • 高温アプリケーションでは,高温のガラス化温度が望ましい.
  • 既存の高温金属ガラスの限られた熱可塑性は,実用的な使用を制限しています.

研究 の 目的:

  • 高温性能を向上した新しい金属ガラスを設計し,発見する.
  • 既存の金属ガラスの狭い超冷却液体の領域の限界を克服する.
  • 望ましい特性を有する新しい金属ガラス組成物を特定するための実用的なアプローチを開発する.

主な方法:

  • イリジウム/ニッケル/タンタール (Ir-Ni-Ta) 基の金属ガラスの設計,ボロン変種を含む.
  • ガラスを形成する能力と電気抵抗性を相関させる簡素化された組み合わせ方法を使用した.
  • 特徴的なガラスの移行温度,超冷却液体領域,機械的強度,およびガラス形成能力 (重要な鋳造厚さ).

主要な成果:

  • 開発されたIr-Ni-Ta-(B) メタリックガラスは,ガラスの移行温度が1,162Kまでであり,超冷却液体領域は136Kです.
  • 1000Kで3.7GPaの高強度を達成し,既存の合金を超えました.
  • 小規模なコンポーネントの熱塑性成形を可能にする 3 mm の重要な鋳型厚さを示した.

結論:

  • 新しく設計された金属ガラスは,高温での特殊な強度と,熱可塑性の向上を示しています.
  • 電気抵抗を用いた組み合わせ方法は,新しい金属ガラスを発見するための効果的な非破壊的な方法です.
  • この研究は,高温や厳しい環境での応用のための先進的な金属ガラスの開発に道を開きます.