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Measurements of Physiological Stress Responses in C. Elegans
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統合ストレス反応におけるeIF2B抑制の構造的基礎

Kazuhiro Kashiwagi1, Takeshi Yokoyama1, Madoka Nishimoto1

  • 1RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

Science (New York, N.Y.)
|May 4, 2019
PubMed
まとめ

ユカリオット翻訳開始因子2 (eIF2) の酸化は統合ストレス反応を調節する. 構造研究は,リン酸化されたeIF2が結合モードを変えることで,そのグアニンヌクレオチド交換因子,eIF2Bを抑制することを明らかにしています.

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