タラミックニューロンの産前活動は,マウスの機能的な皮質マップの出現を制御する
Noelia Antón-Bolaños1, Alejandro Sempere-Ferràndez1, Teresa Guillamón-Vivancos1
1Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
まとめ
感覚の入力ではなく 胚のタラミック活動が マウスの体感覚マップの発達を促します タラムスの自発的なカルシウム波は 機能的な脳回路と皮質構造の形成に不可欠です
科学分野:
- 神経科学
- 発達神経科学
- 感覚システム
背景:
- 哺乳類の体感覚皮質は 体の地形図を形成します
- ネズミの皮質の樽は の入力を表しますが 発達の起源は議論されています
- 地図形成における感覚入力と内在的な活動の役割は不明である.
研究 の 目的:
- バレルのような皮質構造は 発達のために感覚の入力が必要なのか,それとも内在的な活動によって動かされているのかを調査する.
- 体感マップの形成における胚のタラミック活動の役割を決定する.
主な方法:
- 胚性マウスのタラモ皮質柱の発達を研究した.
- 胚性タラムスのカルシウム波の活性をモニターする.
- 皮質回路の発達と体感覚マップの組織を観察した.
主要な成果:
- ネズミの胚では 感覚の入力より前にタラモコルチカルコラムとソマトトピックマップの組織が生まれます
- これらの構造の発達に先行し,それと相関する自発的なタラミックカルシウム波です.
- タラミックカルシウム波の乱れは,過度に興奮する皮質回路,柱状/樽状の組織の欠如,および組織的でない体感覚マップにつながる.
結論:
- 胚性タラムスの自己組織化されたプロトマップは 突発的な活動によって ネズミのタラモ皮質の 感覚回路の形成を指示します
- 感覚経験に先立つ体感覚系の解剖学的および機能的な構成には,内在のタラミック活動が不可欠である.
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