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Updated: Jan 25, 2026

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
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シーシジミシンAのDNA結合と分裂方法

Hao Zhang1, Ruofan Li2, Sai Ba1

  • 1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , Singapore 637371 , Singapore.

Journal of the American Chemical Society
|May 4, 2019
PubMed
まとめ

シシジミシンAは,ベルグマン・サイクロアロマティゼーションによって二重鎖DNAを割って,反応性ダイラジカルを形成する. このメカニズムは,軽微な溝結合とインターケレーションと組み合わせて,その強力な抗がん作用を説明します.

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