強化されたがんイメージングと治療のための調整可能な酸化ストレスを持つ自己組み立ての反応性双層膀

Jibin Song¹, Lisen Lin², Zhen Yang²

¹MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry , Fuzhou University , Fuzhou 350116 , China.

Journal of the American Chemical Society

|May 5, 2019

まとめ

ジャヌスのナノ粒子から磁気プラズマ小胞を作って化学療法を強化しましたこれらの膀は薬物を放出し,腫瘍に反応性酸素種 (ROS) を生成し,治療の有効性を向上させます.

科学分野:

ナノテクノロジー
生物医学工学
材料科学

背景:

化学療法の有効性は,薬剤耐性や副作用によってしばしば制限されます.
がん治療の成果を向上させるには標的型の薬物投与システムが必要です
反応性酸素種 (ROS) の生成は,がん細胞の死を促進する.

研究の目的:

ROS強化化学療法のための新しい磁性-プラズモンの二層膀を開発する.
これらの小胞の自己組織化,特性,治療の可能性を調査する.
腫瘍環境におけるROS生成と化学療法の結合効果を評価する.

主な方法:

鉄酸化物-金ジャヌスナノ粒子 (Fe3O4-Au JNP) を二層の膀に組み立てました.
表面機能化には,ポリエチレングリコール (PEG) とROSを生成するポリリピド水酸化物 (PLHP) が用いられる.
自己組み立てのための数値シミュレーション,光学および磁気特性の実験的検証,pHに対応した解体,およびPET画像を用いた in vivo 研究.

主要な成果:

磁気とプラズモンの結合により,T2の放緩性と光音学性が向上した.
酸性腫瘍環境でのpH反応性分解は局所的なROS生成を誘発した.
ROS媒介の細胞毒性とドクソルビシン (DOX) の化学療法が併用され,治療効果が著しく改善されました.
高度な腫瘍の蓄積と迅速なクリアランスはPET画像で確認された.

結論:

マグネティック・プラズモニック・バイレイヤー・ベシクルは化学療法強化のための有望なプラットフォームです
このpH反応性ROS生成システムは腫瘍を効果的に標的にし治療します
このアプローチはガン治療のナノ医療における重要な進歩です

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