関連する実験動画

Updated: Jan 25, 2026

Identification of Plant Ice-binding Proteins Through Assessment of Ice-recrystallization Inhibition and Isolation Using Ice-affinity Purification
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Published on: May 5, 2017

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Ipomoeassin FはSec61αに結合し,タンパク質の転位を阻害する

Guanghui Zong1, Zhijian Hu, Sarah O'Keefe2

  • 1Department of Chemistry and Biochemistry , University of Maryland , College Park , Maryland 20742 , United States.

Journal of the American Chemical Society
|May 7, 2019
PubMed
まとめ

植物由来の細胞毒素であるイポモエアシンFは,Sec61α (タンパク質輸送タンパク質Sec61サブユニットアルファ同型1) に直接結合し,タンパク質の転位と分泌を抑制する. この発見は,Sec61αを標的としたがん薬の発見に新しい道を開きます.

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