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粒子のメタンモノオキシゲネーゼは,単核銅中心のみを含んでいる
Matthew O Ross1,2, Fraser MacMillan3, Jingzhou Wang4,5
1Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.
Science (New York, N.Y.)
|May 11, 2019
まとめ
メタンを酸化するバクテリアは メタンの排出量を減らすための鍵です この研究では,粒子のメタンモノオキシゲナーゼ (pMMO) において,2つの銅部位が発見され,単一の銅部位がメタン酸化を触媒化することが示唆されています.
科学分野:
- 生物化学
- 環境微生物学
- 生物物理化学
背景:
- メタンは強力な温室効果ガスで メタンを酸化するバクテリアは 温室効果ガスの減少に 重要な役割を果たします
- メタンの酸化を司る酵素である粒子のメタン単酸化酵素 (pMMO) の活性部位は,相反する研究結果のために議論の対象となっている.
- メタンの排出を制御する戦略を策定するには,pMMOの構造と機能を理解することが不可欠です.
研究 の 目的:
- 粒子のメタンモノオキシゲネーゼ (pMMO) の銅活性部位の議論を醸す性質を調査する.
- 前回の研究における不一致を解決するために,pMMOの生化学的およびスペクトル学的性質を特徴づける.
- pMMOによるメタンの酸化に関与する銅の活性部位のモデルを提案する.
主な方法:
- 微粒子のメタンモノオキシゲナーゼ (pMMO) の生化学的特徴
- 電子パラマグネティック共振 (EPR) スペクトロスコーピーは,銅部位を検知する.
- 銅の中心の数と位置を決定するために,光譜学的および生化学的データを分析する.
主要な成果:
- pMMO内の2つの異なる単銅の場所の証拠が見つかりました.
- 1つの銅部位 (CuB) は溶解性PmoBサブユニットにあります.
- 2つ目の銅部位 (CuC) は,膜に結合したPmoCサブユニットに位置し,CuBから約2nmです.
結論:
- この発見は,pMMOには2つのモノコッパーサイトが含まれていることを示唆し,以前のモデルに挑戦しています.
- 一つの単一銅部位がメタンの酸化で触媒的に活性化することが提案されています.
- この研究は,pMMOによるメタンの酸化メカニズムに関する新しい視点を提供します.
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