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学習中の領域特異性および歴史依存の可塑性

Ryoma Hattori1, Bethanny Danskin1, Zeljana Babic1

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まとめ

脳は意思決定のための 主観的な価値をコードします レトロスプレニアル皮質 (RSC) は 価値と歴史のシグナルを 独特に維持しており 適応行動と報酬の歴史の学習に 極めて重要です

キーワード:
意思決定歴史について運動皮質オプトジェネティクスプラスチック性後部頭皮質レトロスプレニアル皮質感覚皮質2フォトン値について

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科学分野:

  • 神経科学
  • 認知神経科学
  • 意思決定科学

背景:

  • 意思決定は経験によって形成された主観的な価値に基づいています.
  • 脳は主観的な価値を 暗号化して維持しなくてはなりません

研究 の 目的:

  • 大脳皮質の領域特異性と可塑性を研究する.
  • 値と履歴信号のエンコーディングにおける特定の皮質領域の役割を決定する.

主な方法:

  • 価値に基づいた意思決定のタスクで訓練されたマウス.
  • 細胞解像度で6つの皮質領域の神経活動をイメージした.
  • レトロスプレニアル皮質 (RSC) の急性無活性化を使用した.

主要な成果:

  • 歴史と価値に関連する信号は広範囲に広がっていたが,皮質領域の強さと時間的なパターンは異なっていた.
  • レトロスプレニアル皮質 (RSC) は,専門家マウスの持続的な活動パターンの歴史と値に関連するシグナルをユニークにコードしました.
  • RSCのユニークなエンコーディングは 学習の過程で生まれました 遠隔の報酬の歴史に対する信号が増加しました
  • RSCの無効化により 報酬履歴に基づく意思決定戦略が 選択的に損なわれました

結論:

  • レトロスプレニアル皮質 (RSC) は,履歴コードを柔軟に更新する上で重要な役割を果たします.
  • RSCは,適応的な意思決定をサポートするために,価値に関連するシグナルを継続的にコードします.
  • 脳皮質のニューラル回路は 値と経歴の信号表現で可塑性を示します