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甲状腺 と 心血管 疾患: 知識,予防,治療 の 向上 の ため の 研究 計画
Anne R Cappola1, Akshay S Desai2, Marco Medici3
1Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.R.C.).
Circulation
|May 14, 2019
まとめ
甲状腺機能障害は 複雑なメカニズムを通して 心血管の健康に影響します 将来の研究は,これらのリンクを理解し,バイオマーカーを特定し,より良い患者の結果のための標的治療を開発することに重点を置くべきです.
科学分野:
- 心臓病科
- 内分泌学
- 分子生物学
背景:
- 甲状腺ホルモンは心臓血管機能に大きな影響を与えます.
- 心血管疾患の患者における甲状腺機能障害の分子メカニズムと最適な管理に関する知識のギャップが残っています.
研究 の 目的:
- 心血管疾患の進行における甲状腺機能障害の役割を理解するための研究優先事項を確立する.
- オミクスとビッグデータを含む研究機会と新しいアプローチを特定する.
主な方法:
- 2017年9月に全国心臓,肺,血液研究所ワーキンググループを招集した.
- 甲状腺の正常な生理学,機能不全の結果,心臓の電気生理学,血管系,心筋への治療効果について検討した.
- 障壁や課題や将来の研究戦略について話し合った.
主要な成果:
- 基礎生物学とバイオマーカー,標的治療のための患者のサブグループ識別,心血管疾患の臨床試験の3つの広範な研究分野を特定しました.
- 心血管組織における甲状腺ホルモンの作用に関する新しいバイオマーカーの研究の必要性を強調した.
- 特定の心血管疾患の予防および介入治療のための患者のサブグループを定義することを強調しました.
結論:
- 甲状腺機能障害と心血管疾患を 関連付ける基礎生物学の研究が急務です
- 甲状腺機能不全の患者の心血管疾患に対する標的型予防と介入戦略の開発は極めて重要です.
- 甲状腺ホルモンの効果や 甲状腺刺激薬の効果を評価するために,臨床試験が必要である.
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