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癌治療のための分離された二段階の金属サイクル内の単片酸素の光制御生成
Yi Qin1, Li-Jun Chen1, Fangyuan Dong1
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200062 , PR China.
Journal of the American Chemical Society
|May 16, 2019
まとめ
研究者は,光動力学的治療のために,制御可能で可逆的なシングレット酸素 (1O2) の生成を可能にする新しい金属サイクルを開発した. この"オフオン"の切り替え可能なシステムは ナノ粒子を介して提供され 光の活性化により 癌細胞を効果的に標的にし 排除します
科学分野:
- 超分子化学
- 材料科学
- ナノテクノロジー
背景:
- シングレット酸素 (1O2) の生成に対する非侵襲的な制御は,光力学療法において極めて重要です.
- 既存の方法は,しばしば1O2の生産に対する正確な時空制御を欠いている.
研究 の 目的:
- 1O2生成の"オフオン"スイッチングのための二段階の金属サイクルを開発する.
- ターゲットを絞ったがん治療のための ナノ粒子ベースの配達システムを作るために
主な方法:
- 光感受剤と光染色スイッチを使って 二段階の金属サイクルを合成した
- 細胞配送用の金属サイクルのナノ粒子を配製した.
- 1O2生成とがん細胞の細胞毒性をin vitroとin vivoで調査した.
主要な成果:
- メタルサイクルは,分子内エネルギー移転による1O2生成の可逆的な"オフオン"スイッチングを示した.
- メタルサイクルのナノ粒子は 癌細胞に効率的に届くことが示されました
- 光活性化リング型ナノ粒子は,閉環型ナノ粒子と比較して,癌細胞に有意に高い毒性を示した.
- 光制御による1O2生成により,有効なin vivo腫瘍除去が達成された.
結論:
- 二段階状態の超分子調整複合体は,制御された1O2生成のための多用途ナノプラットフォームを提供します.
- 開発されたシステムは 非侵襲的な腫瘍治療に 大きな希望を示しています
- このアプローチにより,高度なテラノスティックアプリケーションでは1O2の精密な調節が可能になります.
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