細胞の競争による異なる形状 哺乳類の組織形態変異
Stephanie J Ellis1, Nicholas C Gomez1, John Levorse1
1Howard Hughes Medical Institute, Robin Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Nature
|May 17, 2019
まとめ
細胞の競争は 適合性の低い細胞を排除することで 組織の発達を最適化します ネズミの皮膚では,組織が層分化するにつれて,このプロセスが吸収から排泄へと変化し,適切なバリアを形成します.
科学分野:
- 発達生物学
- 細胞生物学
- 進化生物学
背景:
- "敗者"の細胞を"勝者"の細胞が排除する細胞の競争は,ドロソフィラで初めて観察された.
- その進化的普遍性と脊椎動物の発達における役割は完全に理解されていません.
研究 の 目的:
- ネズミの皮膚の発達中の細胞の競争メカニズムを調査する.
- 細胞の競争が脊椎動物における組織構造と機能を最適化するかどうかを判断する.
主な方法:
- ライブイメージング
- 系統追跡
- 単細胞トランスクリプトミクス
- 遺伝学
主要な成果:
- マウスの皮膚の発達における2つの連続的な細胞競争メカニズムを特定した.
- 早期の表皮は 勝った祖先が 負け犬の細胞を 飲み込みます
- エピダーミスの分層化: 基礎層は,子孫を分化することによって敗者を排出する.
- このスイッチの乱れは皮膚の障壁形成を損なう.
結論:
- 細胞の競争は,脊椎動物の組織機能を最適化する保存された選択力です.
- 組織は体格を維持するために形態変異の間に細胞の競争戦略を動的に調整する.
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