Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Electron Configuration of Multielectron Atoms03:26

Electron Configuration of Multielectron Atoms

64.6K
The alkali metal sodium (atomic number 11) has one more electron than the neon atom. This electron must go into the lowest-energy subshell available, the 3s orbital, giving a 1s22s22p63s1 configuration. The electrons occupying the outermost shell orbital(s) (highest value of n) are called valence electrons, and those occupying the inner shell orbitals are called core electrons. Since the core electron shells correspond to noble gas electron configurations, we can abbreviate electron...
64.6K
Electron Configurations02:46

Electron Configurations

25.7K
Electron configurations and orbital diagrams can be determined by applying the Aufbau principle (each added electron occupies the subshell of lowest energy available), Pauli exclusion principle (no two electrons can have the same set of four quantum numbers), and Hund’s rule of maximum multiplicity (whenever possible, electrons retain unpaired spins in degenerate orbitals).
The relative energies of the subshells determine the order in which atomic orbitals are filled (1s, 2s, 2p, 3s, 3p,...
25.7K
Interference and Diffraction02:18

Interference and Diffraction

51.9K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
51.9K
Controller Configurations01:22

Controller Configurations

366
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
366
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

190
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
190
UV–Vis Spectroscopy: Molecular Electronic Transitions01:16

UV–Vis Spectroscopy: Molecular Electronic Transitions

2.8K
In Ultraviolet–Visible (UV–Vis) spectroscopy, the absorption of electromagnetic radiation is used to probe the electronic structure of molecules. This technique provides insights into molecular electronic transitions, particularly the movement of electrons between different molecular orbitals. Radiation is absorbed if the energy of the electromagnetic radiation passing through the molecule is precisely equal to the energy difference between the excited and ground states. During this...
2.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Evidence for an Electronically Driven Charge Density Wave in a 1D Metallic MOF.

ACS central science·2026
Same author

3D atomic structure determination with ultrashort-pulse MeV electron diffraction.

IUCrJ·2026
Same author

Low-Temperature and High-Pressure Phase Transitions in Two 2‑Amino-4'-halobenzophenones: Incommensurate Modulation and a Case of Temperature-Induced Twinning.

Crystal growth & design·2026
Same author

Round robin on structure analysis from 3D electron diffraction data.

IUCrJ·2026
Same author

Determining chirality in crystalline powders through 3D electron diffraction.

Nature chemistry·2025
Same author

Open Framework Structure of the New Pure-Germania Zeolite ITQ-35 Solved by 3D Electron Diffraction.

Small methods·2025

関連する実験動画

Updated: Jan 24, 2026

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
08:44

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

Published on: August 22, 2017

8.1K

電子 difraktion は,製薬ナノ結晶の分子絶対構成を決定する.

Petr Brázda1, Lukáš Palatinus2, Martin Babor3,4

  • 1Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, 18200 Prague 8, Czech Republic. brazda@fzu.cz.

Science (New York, N.Y.)
|May 18, 2019
PubMed
まとめ

有機分子の絶対的構成を決定することは 薬の開発において極めて重要です この研究は,ナノ結晶の電子 difraksionは,より不安定な製薬コクリスタルの場合でも,これを達成できることを示しています.

さらに関連する動画

Microcrystal Electron Diffraction of Small Molecules
09:48

Microcrystal Electron Diffraction of Small Molecules

Published on: March 15, 2021

7.2K
Using Graphene Liquid Cell Transmission Electron Microscopy to Study in Situ Nanocrystal Etching
06:18

Using Graphene Liquid Cell Transmission Electron Microscopy to Study in Situ Nanocrystal Etching

Published on: May 17, 2018

17.8K

関連する実験動画

Last Updated: Jan 24, 2026

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
08:44

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

Published on: August 22, 2017

8.1K
Microcrystal Electron Diffraction of Small Molecules
09:48

Microcrystal Electron Diffraction of Small Molecules

Published on: March 15, 2021

7.2K
Using Graphene Liquid Cell Transmission Electron Microscopy to Study in Situ Nanocrystal Etching
06:18

Using Graphene Liquid Cell Transmission Electron Microscopy to Study in Situ Nanocrystal Etching

Published on: May 17, 2018

17.8K

科学分野:

  • クリスタルグラフィー
  • 電子微分
  • 薬物開発

背景:

  • 絶対的な構成の決定は,医薬品開発と規制当局の承認のために不可欠です.
  • 以前の電子 difraktion 方法は,非常に安定した結晶材料を必要とした.
  • ソフォスブービルとl-プロリンコクリスタルは,安定性が低いため,問題です.

研究 の 目的:

  • 不安定な製薬コクリスタルの電子 difraktion を用いて絶対的な構成を決定する可能性を実証する.
  • 初期構造の決定のための高度なデータ収集と処理技術を紹介する.
  • 構造分析におけるダイナミック・ディフラクションの役割を強調する.

主な方法:

  • ナノ結晶のソフォスブービル-l-プロリンコクリスタルで電子 difraktion を利用した.
  • 水晶の不安定性を克服するために多位置データ収集を使用しました.
  • アビニシオ構造溶液のための高度な強度抽出手順を実装した.

主要な成果:

  • 薬用コクリスタルの完全な初期構造分析を成功裏に実行しました.
  • 構造の決定は,以前よりもかなり不安定な材料で達成されました.
  • ダイナミック・ディフラクション・エフェクトは 絶対構造の決定を可能にします

結論:

  • ナノ結晶の電子 difraktionは,より不安定な薬剤化合物の絶対的構成を決定するための実行可能な方法です.
  • 先進的なデータ収集と処理は 材料の安定性の限界を克服します
  • ダイナミックな difraktion 効果は,光原子材料の正確な構造の決定のための鍵です.