新生児マウスの行動における下垂体Agrpニューロンの機能的オントジェニー
Marcelo R Zimmer1, Antonio H O Fonseca2, Onur Iyilikci3
1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Graduate Program in Biological Sciences-Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil.
Cell
|May 21, 2019
まとめ
ネズミが食事をする前に,下垂体にあるアグーティ関連ペプチド (Agrp) ニューロンは,飢えではなく,孤立したときに活性化します. これはこれらのニューロンが 早期の子孫と介護者の絆を支える可能性があることを示唆しています
科学分野:
- 神経科学
- 発達生物学
- 行動生物学
背景:
- 下垂体アグーティ関連ペプチド (Agrp) ニューロンは,成人マウスの食物摂取のレギュレータとして知られています.
- これらのニューロンの機能的状態は,独立した栄養の開始前に,ほとんど未知のままです.
研究 の 目的:
- ネズミの産後期初期における下垂体Agrpニューロンの機能的オントジェニスを調査する.
- 新生児マウスのAgrpニューロンを活性化する刺激を決定する.
主な方法:
- 生後10日のマウスのAgrpニューロン活動を監視するために,in vivoファイバーフォトメトリーを使用した.
- Agrpニューロンの活動を操作するために Chemogenetics が使用されました.
- 実験では 哺乳巣から 制御された隔離 牛乳の欠乏 栄養不足の哺乳 温度の変動などが行われました
主要な成果:
- 新生児マウスのAgrpニューロンは 牛乳の摂取や摂取ではなく 哺乳巣からの分離によって 強力に活性化しました
- 栄養不足の哺乳と温かい環境は,Agrpニューロンの活性化を弱めた.
- Agrpニューロンの活動は,隔離時に急速に増加し, littermatesとの再会時に減少しました.
- AgrpニューロンからのGABA放出が低下した新生児は,隔離誘発超音波発声の減少を示した.
- Agrpニューロンの化学的過剰活性化により 超音波発声は増加したが 牛乳の摂取は影響されなかった.
結論:
- 新生児のマウスのAgrpニューロンは,離乳する前に機能的に活性化し,社会的孤立に反応する.
- これらのニューロンは 隔離に関連した 苦痛の発音を媒介する役割があるようです
- この発見は,Agrpニューロンが早期の子孫と介護者との結合を促進する潜在的役割を示唆し,栄養の調節における既知の役割を超えています.
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