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Updated: Jan 24, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

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ホメオスタシスと白血病における骨髄ストロマの細胞分類

Ninib Baryawno1, Dariusz Przybylski2, Monika S Kowalczyk2

  • 1Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Childhood Cancer Research Unit, Dep. of Children's and Women's Health, Karolinska Institutet, 171 77 Stockholm, Sweden.

Cell
|May 28, 2019
PubMed
まとめ

研究者はマウスの骨髄ストロマを単細胞RNA配列解析でマッピングし,17のサブセットを明らかにした. 白血病は正常な骨髄細胞機能を妨害し,癌細胞と特定の構造要素との交響を強調した.

キーワード:
骨髄のニッチ血液形成白血病について単細胞RNAシーケンシング幹細胞ストロマ腫瘍の微小環境

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