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Updated: Jan 24, 2026

Molecular Evolution of the Tre Recombinase
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非正規の有機触媒機構を持つ酵素の設計と進化

Ashleigh J Burke1, Sarah L Lovelock1, Amina Frese1

  • 1Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.

Nature
|May 28, 2019
PubMed
まとめ

研究者はコンピュータ設計と 実験室での進化を用いて 新しい酵素を設計しました この酵素は,改変されたアミノ酸であるNδ-メチルヒスティジンを利用して,エステル水解を効率的に触媒化し,標準的な遺伝子コードの限界を克服します.

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