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メジャー・ヒストコンパティビリティ・コンプレックスIIクラス分子に抗原を提示する能力の欠如は,ApoE/-マウスにおける動脈硬化症を悪化させる

Maria Wigren1, Sara Rattik1, Ingrid Yao Mattisson1

  • 1Department of Clinical Sciences Malmö, Scania University Hospital, Lund University, Sweden.

Circulation
|May 29, 2019
PubMed
まとめ

MHCII経由での抗原表示は,調節性T細胞を活性化することによって,動脈硬化に保護的役割を果たします. MHCIIの損失は動脈硬化症を悪化させ,免疫耐性と心血管の健康におけるその重要性を強調する.

キーワード:
Tリンパ球,レギュレータ抗原を提示する細胞動脈硬化症炎症

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