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Updated: Jan 24, 2026

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BRISC-SHMT2アセンブリの代謝制御は免疫信号を調節する

Miriam Walden1, Lei Tian2, Rebecca L Ross3

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|May 31, 2019
PubMed
まとめ

代謝物質は炎症信号を調節する この研究では,非活性なセリンヒドロキシメチルトランスフェラーゼ2 (SHMT2) ダイマーがBRCC36イソペプチダゼ複合体 (BRISC) を抑制し,サイトカイン応答とI型インターフェロンシグナル伝達に影響を及ぼすことが明らかになりました.

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