関連する実験動画

Updated: Jan 24, 2026

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

691

Caveolin-1は,内皮酸化窒素合成酵素の活性化とは無関係に,低密度リポプロテイントランサイトスおよび血管炎症を弱めることで,アテロゲネシスを調節する

Cristina M Ramírez1,2, Xinbo Zhang1,2, Chirosree Bandyopadhyay3

  • 1Vascular Biology and Therapeutics Program (C.M.R., X.Z., N.R., B.A., J.R.K., V.U., Y.S., W.C.S., C.F.-H.), Yale University School of Medicine, New Haven, CT.

Circulation
|June 4, 2019
PubMed
まとめ

カヴェオリン-1 (Cav1) の欠乏は,酸化窒素 (NO) 産生とは関係なく,脂質の輸送と炎症を変化させることで動脈硬化症を抑制する. これは,Cav1/caveolae が動脈硬化病原性における重要な調節因子であることを強調する.

キーワード:
動脈硬化症カベオラ細胞外マトリックスフィブロネクチン炎症酸化窒素合成酵素III型トランサイトーシス

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