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Updated: Jan 24, 2026

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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乳酸は,MAVSを標的としたRLRシグナリングの自然抑制剤である

Weina Zhang1, Guihua Wang2, Zhi-Gang Xu3

  • 1State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis; State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, National Center of Biomedical Analysis, Beijing, Beijing 100850, China; Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston Salem, NC 27101, USA.

Cell
|June 4, 2019
PubMed
まとめ

糖分解は通常,乳酸を生成することで免疫信号を抑制し,MAVSに結合し,ウイルス防御を防ぐ. I型インターフェロンの産生を促し,免疫力を高める.

キーワード:
MAVSRLRシグナリンググルコース代謝インターフェロン乳酸

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