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Updated: Jan 24, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

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Ca2+/カルモジュリン依存キナーゼIIの阻害によるカテコアミナージックポリモルフ Ventricular Tachycardiaに対する遺伝子療法

Vassilios J Bezzerides1, Ana Caballero1, Suya Wang1

  • 1Basic and Translational Cardiovascular Research and Inherited Cardiac Arrhythmias Programs, Department of Cardiology, Boston Children's Hospital, Harvard Medical School, MA (V.J.B., A.C., S.W., Y.A., R.J.H., F.L., D.A.H.-W., K.D.C., D.Z., D.J.A., W.T.P.).

Circulation
|June 4, 2019
PubMed
まとめ

遺伝子治療は,心筋細胞におけるCaMKIIを標的として,カテコアミナージック多型心室性急性心臓発作 (CPVT) のマウスモデルにおける不律を効果的に抑制した. このアプローチは,ヒトのCPVT幹細胞モデルにおける不律性表型を逆転させました.

キーワード:
心臓発作カルシウムカルモジュリン依存タンパク質キナーゼ2型突然の死遺伝子療法多形性カテキルギー性心室性タヒカルディア

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