関連する実験動画

Updated: Jan 24, 2026

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs
09:45

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

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GPCRのGタンパク質結合選択性を明らかにする

Asuka Inoue1, Francesco Raimondi2, Francois Marie Ngako Kadji3

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan; Advanced Research & Development Programs for Medical Innovation (PRIME), Japan Agency for Medical Research and Development (AMED), Chiyoda-ku, Tokyo 100-0004, Japan; Advanced Research & Development Programs for Medical Innovation (LEAP), AMED, Chiyoda-ku, Tokyo 100-0004, Japan.

Cell
|June 5, 2019
PubMed
まとめ

研究者は148のGタンパク質結合受容体 (GPCR) とGαサブユニット間の相互作用をマッピングしました. 彼らはGPCRのシグナリング特異性を支配する配列特性を特定し,デザイナーGPCRの設計を可能にしました. これは細胞の反応の理解を進めるものです

キーワード:
ドレードGタンパク質結合受容体HEK293 セルナノビットTGF-α 脱落測定法バイオ情報学キメリックGタンパク質予測するタンパク質の設計シグナリング

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