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関連する概念動画

Cross-bridge Cycle01:26

Cross-bridge Cycle

108.8K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
108.8K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.2K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.2K
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

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Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
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Updated: May 4, 2026

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
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Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

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サルコペニア

Alfonso J Cruz-Jentoft1, Avan A Sayer2

  • 1Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.

Lancet (London, England)
|June 8, 2019
PubMed
まとめ
この要約は機械生成です。

サルコペニアは年齢に関連した筋肉障害で 筋肉の質量と機能が低下し 転倒や死亡のリスクが増加します 研究は,より良い臨床実践のための診断,治療,予防戦略に焦点を当てています.

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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle
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関連する実験動画

Last Updated: May 4, 2026

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
07:16

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

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A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle
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科学分野:

  • ゲロントロジー
  • 筋肉生理学
  • 公衆衛生

背景:

  • サルコペニアは,筋肉の質量と機能の喪失によって特徴づけられる進行的な骨格筋疾患です.
  • 老化の一部として高齢者に発症しますが,様々な状態のために中年でも発症することがあります.
  • サルコペニアは,転倒,機能低下,弱さ,死亡などの有害な結果と関連しています.

研究 の 目的:

  • サルコペニアの病理学に関する現在の研究をレビューする.
  • バイオマーカー,栄養介入,薬物開発を含む診断と治療の進歩を探求する.
  • 生涯にわたる予防戦略の開発の重要性を強調する.

主な方法:

  • サルコペニアの研究に関する文献レビュー
  • サルコペニアの病理学に関する現在の理解を分析する.
  • 診断,治療,予防に関連する発見の統合.

主要な成果:

  • サルコペニアの研究は強化され,そのメカニズムを理解することに焦点を当てています.
  • 重要な分野は,信頼できるバイオマーカーと効果的な介入の開発です.
  • 栄養と薬学的アプローチによる抵抗運動の増強は重要な焦点です.

結論:

  • サルコペニアの効果的な診断,治療,予防は高齢者の健康状態を改善するために不可欠です.
  • 終身予防戦略は公衆衛生の主要な関心事です.
  • サルコペニアの管理は,通常の臨床実践に統合される見込みです.