ネズミのニューラル・クライストにおける細胞運命を決定する空間時間構造
Ruslan Soldatov1, Marketa Kaucka2,3, Maria Eleni Kastriti2,3
1Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Science (New York, N.Y.)
|June 8, 2019
まとめ
ニューラル・クライスト細胞は 連続したバイナリ決定によって様々な細胞タイプに 微分化します 幹細胞はニューロンの運命を好む一方,頭蓋骨細胞はTwist1の影響でエクトメンスキームの可能性を発達させる.
科学分野:
- 発達生物学
- 細胞生物学
- 遺伝学
背景:
- 神経頂部細胞は脊椎動物における 重要な胚の祖先である.
- 神経頂部の細胞運命を理解することは 発達生物学にとって鍵となるものです
研究 の 目的:
- ネズミの幹細胞と頭蓋骨の神経頂細胞の系統選択と意思決定プロセスを解明する.
- 転写因子Twist1が頭蓋骨神経の発達に果たす役割を調査する.
主な方法:
- ニューラル・クライストの細胞群を研究するために単細胞分析が採用された.
- 計算モデリングは,細胞の運命決定を決定ツリーとして公式化するために使用されました.
主要な成果:
- トランクニューラル・クライスト細胞は,神経系への初期のバイアスを示します.
- 頭蓋骨の神経頂部細胞は,ectomesenchymeポテンシャルのためにTwist1の活性化を必要とします.
- 細胞の運命決定には,バイポテンシャル特性と競合する運命プログラムの共同活性化があり,その後に段階的なコミットメントと特定のプログラムの同期が続きます.
結論:
- 神経頂部細胞の運命決定は,連続したバイナリ決定としてモデル化することができます.
- 特定の運命へのコミットメントは 関連する遺伝子発現プログラムを同期し 競合するものを抑制することを含みます
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