食品の安全性の社会的伝播は,前頭前皮質のシナプス可塑性に依存しています
Michaël Loureiro1, Ridouane Achargui1, Jérôme Flakowski1
1Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.
Science (New York, N.Y.)
|June 8, 2019
まとめ
マウスは匂いを嗅いで 食品の安全性を知っています 食物嗜好の社会的伝播は,嗅覚知覚と行動を結びつける,中央前頭前皮質 (mPFC) のシナプス可塑性を含みます.
科学分野:
- 神経科学
- 嗅覚処理
- 社会的な学習
背景:
- 動物は嗅覚や社会的なシグナルを使って 食物摂取を決定します
- ピリフォームム皮質 (PiC) は嗅覚情報を処理し,核アキュンベンス (NAc) は消費に関与する.
- 嗅覚知覚を 価値に基づく行動に変換する神経基盤は 完全に理解されていません
研究 の 目的:
- 食品の安全性の社会的伝播の基礎にある神経回路と細胞メカニズムを調査する.
- 同種の動物から食品の安全性に関する学習に関与する脳の領域とシナプスプロセスを特定する.
主な方法:
- マウス間の食物情報の社会的伝達過程で,前頭前皮質 (mPFC) のニューロンの活動を監視する.
- NAcを投射するニューロンの刺激後シナプス電流の測定.
- その役割を評価するために,PiCからmPFCへの神経伝送をブロックします.
主要な成果:
- 食物情報の社会的伝達後にNAcに投影されるmPFCニューロンにおいて,神経細胞の活性が強化されたことが観察された.
- NAcプロジェクターにおける同種の潜在刺激性ポストシナプス電流への曝露.
- PiCからmPFCへの伝播を抑制することで 食品の安全性の社会的伝播は廃止されました
結論:
- mPFCのシナプス性可塑性は,食品の安全性の社会的伝達のための細胞基板として機能する.
- このプロセスには,PiCからmPFCからNAcまでの神経経路が重要です.
- この研究は 社会的嗅覚が 食品の受容性に 影響する様子を明らかにしています
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