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Updated: Jan 23, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

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内皮のフォークヘッドボックスの転写因子P1は,成長因子-β1-内皮リン-1信号経路を変換することによって,病理的な心臓の改造を調節する

Jie Liu1, Tao Zhuang1, Jingjiang Pi2

  • 1Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (J.L., T.Z., X.C., Z.Y., L.Z., Z.L., Y.Z.), Tongji University School of Medicine, China.

Circulation
|June 11, 2019
PubMed
まとめ

内皮細胞 (ECs) のフォークヘッドボックス転写因子P1 (Foxp1) は,病的な心臓の改造を防止する上で重要な役割を果たします. EC-Foxp1-TGF-β1-endothelin-1経路を標的とした治療は,心不全の新たな治療法となる可能性があります.

キーワード:
アンジオテンシンII内皮細胞エンドセリン-1繊維症心不全ハイパートロフィー変換成長因子 beta1室内リモジリング

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