Piwi/PRG-1 アルゴナウトとTGF-βは,世代を超えた学習病原性回避を媒介する
Rebecca S Moore1, Rachel Kaletsky1, Coleen T Murphy1
1Department of Molecular Biology & LSI Genomics, Princeton University, Princeton, NJ 08544, USA.
Cell
|June 11, 2019
まとめ
C.エレガンスの病原性細菌の回避は,生殖線伝播を通じて世代を超えて受け継がれます. PRG-1とDAF-7に依存するこの世代を超えた表遺伝子遺伝は,子孫の生存率を高めます.
科学分野:
- エピジェネティクス
- 行動神経科学
- 発達生物学
背景:
- 学習した行動の遺伝は 子孫の生存に進化的利点をもたらします
- 環境からの曝露は遺伝的遺伝子発現変化を引き起こす.
研究 の 目的:
- カエノラビティス・エレガンスにおける 学習された回避行動の 世代間遺伝を調査する.
- この遺伝的行動の基礎にある 分子メカニズムを特定する
主な方法:
- Pseudomonas aeruginosa (PA14) の学習回避を評価するための行動分析
- PRG-1とDAF-7に対するC. elegans変異体による遺伝子解析
- 感覚神経細胞 (ASI) と生殖系における遺伝子発現の分析.
主要な成果:
- C.elegansの子孫は最大4世代に渡ってPA14の回避行動を受け継いだ.
- この遺伝には,ASIニューロンにおけるTGF-βリガンドと,Piwi経路の成分であるPRG-1が必要であった.
- 遺伝的回避は,PRG-1に依存するPA14に対する生存優位性を与えた.
結論:
- 学習された病原体回避の世代間表遺伝子遺伝は,C. elegansで可能である.
- DAF-7とPRG-1を含むこのメカニズムは,危険な環境での子孫の生存を最適化します.
- 学習された行動の表遺伝子遺伝は,変動する条件における重要な適応戦略である可能性があります.
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