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Updated: Jan 23, 2026

Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli
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Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli

Published on: February 5, 2019

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DNA塩基編集によって誘発される非標的RNA変異と,変異性によって排除される

Changyang Zhou1,2, Yidi Sun2,3,4, Rui Yan5

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Nature
|June 11, 2019
PubMed
まとめ

DNA 塩基エディタは RNA 変異を広範囲に 引き起こすことがあり,以前は安全性の問題として見過ごされていました. 研究者はDNA編集効率を維持しながらも 対象外RNA編集を排除する変種を設計した.

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