移住した記憶B細胞は,陰道で光抗体を分泌する
Ji Eun Oh1, Norifumi Iijima1,2,3, Eric Song1
1Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Nature
|June 14, 2019
まとめ
女性の生殖器系では,循環する記憶B細胞が二次感染時に迅速に抗体を分泌します. このメカニズムは地元のプラズマ細胞をバイパスし,ヘルペス・シンプレックスウイルス2のような病原体に対する粘膜免疫のための新しい経路を提供します.
科学分野:
- 免疫学
- 粘膜免疫
- 生殖 健康
背景:
- 粘膜の障壁は病原体から保護し,腸道 (I型粘膜) で二次性IgAを介する.
- 女性の下生殖器 (II型粘膜) への抗体伝達は,局所的なプラズマ細胞とポリマー免疫グロブリン受容体が限られているため,十分に理解されていません.
研究 の 目的:
- 女性の生殖管の光に抗体を送るメカニズムを調査する.
- 女性生殖器系を感染から守る 抗体の源を特定する
主な方法:
- マウスの性器ヘルペス感染モデル
- 女性生殖器の血細胞,記憶B細胞,T細胞の反応の分析
- ケモカインと受容体の関与の調査 (CXCL9,CXCL10,CXCR3).
主要な成果:
- 主要な生殖器ヘルペス感染症は女性の生殖管内膜にプラズマ細胞を確立しなかった.
- 循環する記憶B細胞は 血管に入り,抗体を分泌します
- CD4組織に存在する記憶T細胞は,CXCR3経由で記憶B細胞を誘発するケモカインであるインターフェロン-γを産生した.
- ウイルス特異のIgG2b,IgG2c,IgAは,リクルートされた記憶B細胞によって,光膜に分泌された.
結論:
- 循環する記憶B細胞は,女性の生殖管の光の中で抗体の主要な源です.
- このメカニズムは女性生殖器の下部で迅速で誘導可能な粘膜免疫を提供します.
- この部位における抗体介護の新たな経路を特定し,タイプI粘膜とは異なる.
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