オートファジー装置のオートファジー独立機能

Lorenzo Galluzzi¹, Douglas R Green²

¹Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université Paris Descartes/Paris V, Paris, France.

Cell

|June 15, 2019

まとめ

細胞の分解過程であるマクロオートファギーはタンパク質のオートファージ機能を超えて重要な役割を果たしますこの研究では,重要なオートファジー関連のタンパク質の新興の非オートファージ機能を探索しています.

科学分野:

細胞生物学
分子生物学
生物化学

背景:

マクロオートファジー (オートファジー) は,細胞成分を分解する基本的な細胞プロセスである.
各種のオートファギーの分子メカニズムを理解する上で大きな進展がみられた.
オートファジー機械の部品は,オートファージ経路から独立して機能することをますます認識しています.

研究の目的:

オートファジーに関与するタンパク質の非オートファージ機能に関する新しいデータをレビューし,議論する.
セルラープロセスにおけるオートファジー関連のタンパク質の二重な役割を強調する.

主な方法:

オートファジーとその構成要素に関する最近の研究の文献レビュー.
オートファジーに関連するタンパク質の非オートファージ的役割を支持する実験的証拠の分析.

主要な成果:

すべてのタンパク質がそうでない場合でも,ほとんどのタンパク質は,自己消化機構に不可欠な機能を持っています.
これらの非オートファージ的役割は,様々な細胞プロセスにとって重要です.
新たに得られたデータは,以前に理解されていたよりも,オートファジーに関連するタンパク質の機能スペクトルの幅が広いことを示している.

結論:

オートファジーに関連するタンパク質は,分解における正規の役割を超えて,細胞の調節に多岐にわたる役割を果たします.
これらの非オートファージ機能を理解することは細胞生物学と病気の総合的な見方にとって不可欠です
これらの二重の役割のメカニズムと影響を完全に解明するために,さらなる研究が必要である.

キーワード:

ATG5 について BECN1 について LC3に関連したファゴサイトーシス拡散制御された細胞死膀の密輸

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