完全な適応を可能にするユニバーサルなバイオ分子フィードバックコントローラ

Stephanie K Aoki¹, Gabriele Lillacci¹, Ankit Gupta¹

¹Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

Nature

|June 21, 2019

まとめ

研究者は強力な生物学的規制のための合成統合フィードバックコントローラを設計しましたこの突破は生体細胞の完璧な適応を可能にしますこれまでの合成生物学の課題を克服します

科学分野:

合成生物学
システム生物学
制御理論

背景:

ホメオスタシスは生物学的変数の環境変化への適応を統合制御で保証する.
統合フィードバックの合成実現は,生物学的計算の複雑さのために困難でした.

研究の目的:

積分フィードバックのための基本的な生物分子コントローラトポロジを数学的に証明する.
生体細胞の合成フィードバックコントローラを遺伝子工学的に設計し実証する

主な方法:

コア・コントローラ・トポロジを特定するための数学的モデリング.
合成フィードバック制御装置の遺伝子工学
エシェリキア・コライの成長率の制御のための適用

主要な成果:

統合フィードバックを実現する単一のバイオ分子コントローラトポロジーが特定されました.
合成コントローラが生体細胞に完璧な適応性を示しました
コントローラーは,成長率調節アプリケーションで調節性と堅実性を示した.

結論:

この研究は,生物学的システムにおける合成制御装置の設計のための概念的および実用的な枠組みを提供します.
不確実な細胞内ネットワークにおける生物学的変数を調節するための汎用的なツールを提供します.
この研究は生命体のダイナミクスを精密に制御することを可能にすることでサイバー遺伝学の分野を前進させています

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関連する実験動画

完全な適応を可能にする ユニバーサルなバイオ分子フィードバックコントローラ