初期の肺状がんの腫瘍侵入前の免疫回避

Céline Mascaux^1,2,3,4,5,6, Mihaela Angelova^7,8,9,10,11, Angela Vasaturo^7,8,9,10

¹Department of Intensive Care and Thoracic Oncology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium. celine.mascaux@chru-strasbourg.fr.

Nature

|June 28, 2019

まとめ

免疫の活性化と脱出は肺がんの侵入に先立ちます研究者は,侵襲前段階で重要な免疫バイオマーカーを特定し,高リスクの個人に新しい早期発見と免疫療法戦略を提案しました.

科学分野:

腫瘍学
免疫学
分子生物学

背景:

癌の早期発見と治療は患者の健康状態にとって極めて重要です
癌発生を理解するには腫瘍前病変と腫瘍の免疫マイクロ環境を研究する必要があります
適応免疫反応は,がんの初期段階で最も強くなります.

研究の目的:

肺がん発生における腫瘍侵入前の免疫活性化と脱出メカニズムを調査する.
肺がん前段階の免疫バイオマーカーを特定するためです
細胞の共進化と免疫反応を理解するために

主な方法:

遺伝子表現プロファイリングと多スペクトル画像
肺状細胞がんの9つの形態学的段階の生検を分析した.
癌の進化経路と免疫経路の検討

主要な成果:

特定された異なる段階: 増殖/DNA修復の線形増加,低度病変における一時的な免疫感知,高度病変における免疫活性化/脱出,侵襲性癌における上皮-メゼンキマ移行.
腫瘍の侵入前に免疫活性化と脱出が示されている.
肺癌前発症に関連する特定の免疫バイオマーカーを明らかにした.

結論:

肺がん発生には侵襲前細胞と免疫系のダイナミックな共同進化が含まれます
発見は,肺がんを早期発見するための免疫バイオマーカーの開発を支持しています.
高リスク集団における免疫療法による化学予防の可能性を示唆している.

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