哺乳類の臓器と種の間で lncRNA の発達動態

Ioannis Sarropoulos¹, Ray Marin², Margarida Cardoso-Moreira^3,4

¹Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.

Nature

|June 28, 2019

まとめ

研究者は7種の臓器発達の過程で長い非コーディングRNA (lncRNAs) を調査した. 彼らは多くの lncRNA が種特異で動的に発現することを発見し,開発における重要な役割を示唆しました.

科学分野:

ゲノミクス
発達生物学
進化生物学

背景:

長い非コーディングRNA (lncRNAs) は豊富であるが,機能的には特徴が不十分である.
種間の臓器発達の役割はほとんど不明です

研究の目的:

臓器発達の過程で lncRNAの発現パターンを体系的に分析する.
哺乳類の臓器形成と進化に関与する lncRNA 候補を特定する.

主な方法:

7種 (ヒト,レサス・マカク,マウス,ラット,ウサギ,オポッサム,鶏) の間で lncRNA発現の比較分析.
7つの主要な臓器の多重な発達期にわたる表現のプロフィールです
種特有の保存された lncRNA の識別と特徴付け.

主要な成果:

種別特異性の高い1万5千〜3万5千の候補 lncRNA を特定した.
発達段階における多くの lncRNA の動的発現パターンを観察した.
遺伝子の保存から系統と器官特異の lncRNA への進化のシフトを発見した

結論:

lncRNAは臓器発達の過程でダイナミックで種特有の発現を示します.
これらの発見は,臓器形成における lncRNA 機能の研究に貴重なリソースを提供します.
lncRNAの進化は,発達の過程で特化する傾向を示している.

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