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Updated: Jan 22, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
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FOXA1変異は,先駆的な活動,差別化,前立腺がんのフェノタイプを変化させる

Elizabeth J Adams1, Wouter R Karthaus1, Elizabeth Hoover1

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|June 28, 2019
PubMed
まとめ

転写因子FOXA1の変異は,そのDNA結合および開拓機能を変化させ,前立腺がんの進行に影響を与えます. これらの変化は,機能の獲得につながり,正常な細胞の分化を阻害し,攻撃的な腫瘍のフェノタイプを促進します.

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