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Updated: Jan 22, 2026

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UDPグルコースは,SNAI1 mRNAの分解を加速し,肺がんの転移を阻害する

Xiongjun Wang1,2,3, Ruilong Liu1,2, Wencheng Zhu1

  • 1State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.

Nature
|June 28, 2019
PubMed
まとめ

UDP-グルコース6脱水素酶 (UGDH) は,SNAI1 mRNAを安定させることで肺がんの転移を促進する. このプロセスにはUGDHのリン酸化が関与し,腫瘍細胞の移動を高め,患者の予後が悪いことを予測します.

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