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Updated: Jan 22, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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Published on: May 10, 2022

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Cdc48 ATPase複合体による基板の処理は,ユビキチン展開によって開始されます

Edward C Twomey1, Zhejian Ji1, Thomas E Wales2

  • 1Department of Cell Biology, Harvard Medical School, and Howard Hughes Medical Institute, 240 Longwood Avenue, Boston, MA 02115, USA.

Science (New York, N.Y.)
|June 29, 2019
PubMed
まとめ

Cdc48 ATPase複合体は,Ufd1/Npl4の共因子で,ウビキチンを解析してポリウビキチン化タンパク質を抽出する. このメカニズムは,Cdc48がタンパク質分解のために多様な,よく折りたたまれた基板を処理することを可能にします.

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