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Updated: Apr 7, 2026

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異常なアミダースの反応性は,コリバクチンのDNAクロスリンク活動を説明する可能性がある

Yindi Jiang1, Alessia Stornetta2, Peter W Villalta2

  • 1Department of Chemistry and Chemical Biology , Harvard University , 12 Oxford Street , Cambridge , Massachusetts 02138 , United States.

Journal of the American Chemical Society
|June 29, 2019
PubMed
まとめ

細菌の遺伝子毒であるコリバクチンは,その生物合成酵素ClbLによってDNAのクロスリンクを形成する. この酵素は基板と結合し DNA損傷の原因となる サイクロプロパン弾頭を生成します

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