脳幹GABAニューロンによるエネルギー消費の調節
Marc Schneeberger1, Luca Parolari1, Tania Das Banerjee2
1Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Cell
|July 2, 2019
まとめ
脊髄核 (DRN) のニューロンは体温とエネルギー消費を調節します これらのGABAergic (Vgat発現) ニューロンの活性化は,直接的および間接的な経路を通じて発熱と移動に影響を与えます.
科学分野:
- 神経科学
- 生理学
- 温度調節
背景:
- ホメオスタティックな体温制御は 生存に不可欠です
- ニューロンは温度を感知し 運動や発熱などの 行動や生理学的反応を起こすのです
研究 の 目的:
- 背面ラフェ核 (DRN) の特定のGABAergicニューロンのエネルギー消費と熱調節の役割を調査する.
- これらのDRNニューロンの投影標的と制御経路を特定する.
主な方法:
- 背側DRNのVgat発現ニューロンを刺激し,記録するために光遺伝学を使用しました.
- ラフェ・パリドゥス (RPa),下垂体,拡張 amigdala へのニューロンの投影を追跡した.
- 熱生成と運動に対する神経刺激の影響を評価した.
主要な成果:
- 背面ラフェ核のVgat発現 (DRNVgat) ニューロンは熱によって活性化される.
- DRNVgatニューロンはエネルギー消費を双方向に制御し,熱生成と運動に影響します.
- これらのニューロンはRPa,下垂体,および拡張 amigdalaに投影され,直接的および間接的な経路を通じて温度調節を媒介します.
結論:
- DRNVgatニューロンは エネルギー消費を制御し 体温を維持する上で重要な役割を果たします
- RPaへの下降プロジェクションと,下垂体/桃体への上昇プロジェクションの両方が熱調節に貢献します.
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