視覚的に誘導された行動を,皮質アンサンブルのホログラムリコールによって制御する
Luis Carrillo-Reid1, Shuting Han1, Weijian Yang1
1NeuroTechnology Center, Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Cell
|July 2, 2019
まとめ
ネズミの視覚皮質の特定のパターン完成ニューロンを活性化することで ニューロンの集合が 行動に因果的に結びつきます この研究は 集合体が知覚状態を表し 視覚的なタスクの実行に影響を与えることを示しています
科学分野:
- 神経科学
- システム神経科学
- 計算神経科学
背景:
- 皮質のニューロンはしばしば集合体として活性化しますが 行動における機能的役割は不明です
- いくつかのニューロンはパターンの完成を示し,刺激を受けたときに全体のアンサンブルを活性化します.
研究 の 目的:
- パターン完成ニューロンを活性化することによって,行動におけるニューロン集合の因果的役割を調査する.
- 視覚的なタスクのパフォーマンスに影響を及ぼすかどうかを判断する.
主な方法:
- マウスの主視野皮質に 2フォトンのホロジェネティクスを使った
- 特定のパターンの完成ニューロンと,行動的に関連する集合体内の非選択ニューロンを活性化します.
主要な成果:
- 非選択性ニューロンを活性化すると 集合体が破壊され 行動能力が低下します
- パターン完成ニューロンを2つだけ活性化することで 信頼性の高いアンサンブルをリコールすることで 性能が向上しました
- 不適切なアンサンブルの活性化により 間違った行動が生まれました
- 視覚的刺激なしに 集団の活性化が 正しい行動反応を誘発する
結論:
- ニューロンの集合体は視覚的に導かれた行動に 原因的な役割を果たします
- アンサンブルは,知覚状態の内部表現を実装する可能性が高い.
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