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Updated: Jan 22, 2026

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
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トランスクリプトームのゲノタイプ化によって結びついた体内変異と細胞同一性

Anna S Nam1,2,3, Kyu-Tae Kim2,3,4, Ronan Chaligne2,3,4

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Nature
|July 5, 2019
PubMed
まとめ

トランスクリプトームの遺伝子型決定 (GoT) は,単細胞RNA配列決定と遺伝子型決定を統合することによって,がん細胞のトランスクリプトームをプロファイルします. この方法は,CALR変異が骨髄増殖性腫瘍における血液細胞発達の影響を明らかにします.

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