コバルト触媒による地域およびエナチオ選択性アリルアミネーション
Samir Ghorai1, Sahadev Shrihari Chirke1, Wen-Bin Xu1
1Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering Shanghai Jiao Tong University , 800 Dongchuan Road , Shanghai 200240 , China.
Journal of the American Chemical Society
|July 6, 2019
まとめ
新しいコバルト触媒反応により,簡単に入手可能な出発材料から有価なアリルアミンの効率的な合成が可能になります. この方法は,高収量,独占的な分岐選択性,および穏やかな条件下で優れたエナチオ選択性を達成します.
科学分野:
- 有機化学
- カタリシス
- 非対称合成
背景:
- アリルアミンは医薬品や天然製品の重要な構成要素です.
- 合成のための効率的で選択的な方法の開発は重要な関心事である.
- 既存の方法はしばしば貴金属触媒に依存するか,高いエナチオ選択性がない.
研究 の 目的:
- 地球に豊富に存在するコバルト触媒によるエナチオセレクティブアリルアミネーションを開発する.
- ラセミカルアリル炭酸から高分岐アリルアミンを合成する.
- 高い収穫量,枝分かれした選択性,そして優れたエナチオ選択性を得るために.
主な方法:
- コバルトの触媒を 地中に豊富な金属で使った
- アリル炭酸と様々なアロマティック・アリファティック・アミンが使用されている.
- 温和で効率的な反応条件を最適化しました.
主要な成果:
- コバルト触媒による高度な分岐とエナチオセレクティブのアリルアミネーションを初めて成功させた.
- アリルアミンは高収量で得られた.
- 枝分かれした選択性と優れたエナチオ選択性 (通常99% ee) を示した.
結論:
- エナチオメリックに濃縮されたアリルアミンを合成するための実用的で効率的な方法を開発した.
- 地球に豊富なコバルトの使用は,貴金属触媒の持続可能な代替手段を提供します.
- この方法論は,価値あるキラル・ビルディング・ブロックへの迅速なアクセスを提供します.
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