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Updated: Jan 22, 2026

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

Published on: March 25, 2020

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VEGAS は 哺乳類 の 細胞 の 容易 な 進化 の 基盤

Justin G English1, Reid H J Olsen1, Katherine Lansu1

  • 1Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27514, USA.

Cell
|July 9, 2019
PubMed
まとめ

哺乳類の細胞における指向的な進化は,遺伝的に活性化する配列 (VEGAS) システムのウイルスの進化を用いて容易である. この方法は,原生細胞環境でタンパク質を進化させることで,分子ツールと治療薬の急速な開発を可能にします.

キーワード:
Gタンパク質結合受容体GPCR について人工選択哺乳類による進化分子薬理学ナノボディ転写因子ウイルス工学

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