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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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サブクリニック の 甲状腺 機能 低下: レビュー

Bernadette Biondi1, Anne R Cappola2,3, David S Cooper4

  • 1Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

JAMA
|July 10, 2019
PubMed
まとめ

甲状腺を刺激するホルモン (TSH) が上昇し,自由タイロキシンは正常である. ほとんどの症例は治療を必要としませんが,10 mU/L以上のTSHレベルまたは症状のある若い個体では介入が必要になります.

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科学分野:

  • 内分泌学
  • 内科 医学
  • 高齢者医療

背景:

  • サブクリニカルな甲状腺機能低下症 (TSH上昇,正常FT4) は,成人の最大10%に影響する.
  • 高齢化により,TSHが増加し,高齢者の過剰診断につながる可能性があります.
  • 関連するリスクには,心血管疾患や認知障害が含まれます.

研究 の 目的:

  • サブクリニカルな甲状腺機能低下症の定義,流行,および管理をレビューする.
  • レボチロキシン治療のリスクと利点について説明します.
  • 治療の指示に関するガイドラインを提示する.

主な方法:

  • サブ臨床的甲状腺機能低下に関する研究の文献レビュー.
  • 老化している集団における TSH レベルの分析
  • 治療結果とリスクの評価

主要な成果:

  • TSHレベルは年齢とともに自然に上昇し,高齢者の診断を複雑にします.
  • 甲状腺過酸化酵素抗体を持つ人では,明らかな甲状腺機能低下症に進行する可能性が高い.
  • レボチロキシン治療は,65歳以上の患者に効果が証明されず,リスクも伴う.

結論:

  • ほとんどのサブ臨床的甲状腺機能低下は観察によって管理できます.
  • 治療は,TSH ≥10mU/ Lまたは症状のある若い/ 中年の患者で検討されます.
  • 年齢と症状を慎重に考慮することは,治療の決定において極めて重要です.