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エナチオセレクティブ・フォールディング・オブ・エネス・バイ・ゴールド (I) リモートC2-キラル・エレメントを持つ触媒

  • 0Institute of Chemical Research of Catalonia (ICIQ) , Barcelona Institute of Science and Technology , Av. Països Catalans 16 , 43007 Tarragona , Spain.
Journal of the American Chemical Society +

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2019年7月11日

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2019年7月11日

PubMedで要約を見る

まとめ

この要約は機械生成です。

新しいキラルゴールド () 触媒は1,6-エニンのエナチオセレクティブサイクリングを可能にします. これらの触媒は,カレキサン天然産物の最初の完全合成に使用され,基板の折り畳みによるステレオ化学の制御を示した.

科学分野

  • 有機金属化学
  • 非対称な触媒
  • 自然製品合成

背景

  • チラルゴールド (I) 触媒は非対称合成に不可欠である.
  • 効果的なキラルリガンドの設計は,エナチオ選択性を制御する鍵です.
  • 1,6-エニンは,循環反応のための多用途の基質である.

研究 の 目的

  • 新しいキラルゴールドを設計する.
  • これらの触媒を1,6-エニンのエナンチオセレクティブサイクリングに使用する.
  • カレキサン天然産物の 完全合成を初めて行いました

主な方法

  • ディスタルC2-2,5 - ディアリルピロリジンを含む改変したジョンフォスのリガンドの合成.
  • キラル単核金 (I) 触媒の開発
  • 1,6-エニンの5-エクソディグおよび6-エンドディグサイクルにおける触媒の適用.
  • 自然製品のステレオ化学分析と総合合成

主要な成果

  • 設計された触媒は,エナンチオセレクティブの5 - エクソディグと6 - エンドディグのサイクルを効果的に促進します.
  • カレキサンファミリーの3つの成分のエナチオセレクティブ・トータル合成が成功しました.
  • 基板の折りたたみとアリル-アリル相互作用による類似反応における対極なエナンチオ選択性の実証.

結論

  • 新規のキラルゴールド (C2-キラル元素) 触媒は,1,6-エニンサイクルで高いエナチオ選択性を提供する.
  • 触媒の設計は,ステレオ化学的結果の正確な制御を可能にします.
  • この研究は非対称な触媒と自然産物合成を進める.

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