ゼブラフィッシュ の 睡眠 の 神経 信号
Louis C Leung1, Gordon X Wang1, Romain Madelaine1
1Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nature
|July 12, 2019
まとめ
研究者達は2つの主要な睡眠のサインを 発見しました ゆっくりと爆発する睡眠と 波のように広がる睡眠です これは脊椎動物における 睡眠パターンの古代の起源を示唆しています メラニン濃縮ホルモンのシグナル伝達も ゼブラフィッシュの睡眠に影響します
科学分野:
- 神経科学
- 比較生物学
- 睡眠に関する研究
背景:
- スローウェーブ・スリープや 急速眼球運動 (REM) のような睡眠のサインは 哺乳類や鳥類やトカゲに記録されています
- 乳房以外の脊椎動物にも同様の神経睡眠のサインが存在するかどうかは不明である.
- ゼブラフィッシュは脊椎動物生物学と神経科学の研究の重要なモデル生物である.
研究 の 目的:
- 乳液のない脊椎動物であるゼブラフィッシュの睡眠シグネチャーの存在と性質を調査する.
- 脊椎動物の睡眠パターンの 進化的起源を探るため
- ゼブラフィッシュの睡眠を制御する 分子経路を特定するために
主な方法:
- 斑馬魚のための非侵襲的,光ベースのポリソムノグラフィーの開発.
- 偏見のない脳活動記録
- 眼の動き,筋肉の動態,心拍の同時評価
主要な成果:
- 少なくとも2つの主要な睡眠のサインを特定しました ゆっくりと爆発する睡眠と拡散する波の睡眠です
- これらのシグネチャーは,哺乳類の遅波睡眠とパラドックスな (REM) 睡眠との共通点を示しています.
- メラニン濃縮ホルモンのシグナリングは,伝播波の睡眠とゼブラフィッシュの全体的な睡眠期間を,潜在的にエペンジマ細胞を通じて調節する.
結論:
- 睡眠に関するニューラルシグネチャーは 4億5千万年前に 脊椎動物の脳で生まれました
- ゼブラフィッシュは哺乳類に似た 複雑な睡眠パターンを表しています
- メラニン濃縮ホルモンの経路は脊椎動物の睡眠調節に保存されます.
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