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関連する概念動画

Gap Junctions01:27

Gap Junctions

9.4K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.4K
Gap Junctions01:37

Gap Junctions

57.0K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.0K
Structural Protein Function01:56

Structural Protein Function

29.8K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.8K
Structural Protein Function01:56

Structural Protein Function

3.2K
3.2K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.0K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
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Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

5.3K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
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関連する実験動画

Updated: Jan 22, 2026

A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide
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A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide

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バクテリア・ギャップ・ジャンクション・アナログの構造と機能

Gregor L Weiss1, Ann-Katrin Kieninger2, Iris Maldener2

  • 1Department of Biology, Institute of Molecular Biology & Biophysics, Eidgenössische Technische Hochschule Zürich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland.

Cell
|July 13, 2019
PubMed
まとめ

多細胞サイアノバクテリアは 細胞の伝達のために 隔膜の交差点を利用します ストレスにより これらの結合が逆転的に閉ざされ 分子交換と細胞の分化が制御されます

キーワード:
細胞同士の接続シアノバクテリア電子冷凍写真光白化後の光回復膜の密輸多細胞性隔膜の交差点サブトモグラムの平均

さらに関連する動画

Recording Gap Junction Current from Xenopus Oocytes
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Recording Gap Junction Current from Xenopus Oocytes

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An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
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An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

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関連する実験動画

Last Updated: Jan 22, 2026

A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide
11:02

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Published on: October 18, 2014

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Recording Gap Junction Current from Xenopus Oocytes
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Recording Gap Junction Current from Xenopus Oocytes

Published on: January 21, 2022

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An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
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An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

Published on: February 1, 2019

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科学分野:

  • 微生物学
  • 細胞生物学
  • 構造生物学

背景:

  • 多細胞性とは 細胞同士の繋がりによる コミュニケーションと分化です
  • シアノバクテリアのセプタル・ジャンクションは細胞間分子交換に不可欠ですが,その構造と機能は十分に理解されていません.

研究 の 目的:

  • シアノバクテリアの隔膜の位置構造を解明する.
  • ストレス下での細胞間通信の制御における 隔膜の関節の役割を調べる

主な方法:

  • 電子クリオトモグラフィーで,イオンビームで磨かれたシアノバクテリアのフィラメント.
  • 細胞間通信を評価するために,光白化後の光回復 (FRAP).

主要な成果:

  • Septal junctionはペプチドグリカンを通ってチューブを形成し,それぞれの端にFraDを含むプラグとサイトプラズミックキャップがあります.
  • 細胞間通信は ストレス状態で遮断されます
  • ストレス誘発のゲーティングは,隔膜の結合キャップの可逆的な形状の変化を含みます.

結論:

  • この研究は,シアノバクテリアの隔膜結合の詳細な構造を明らかにし,その機能のメカニズム的枠組みを提供します.
  • これらの古代の細胞結合は 分子交換を制御する ゲート付きのメカニズムを示し 生涯にわたって保たれています
  • このゲーティングメカニズムは多細胞生物の細胞分化を制御するために不可欠です.