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Updated: Jan 22, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

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エンジニアリングされたヒト心臓組織からのカテコラミナージックポリモルフ Ventricular Tachycardia の病原性への洞察

Sung-Jin Park1, Donghui Zhang2,3, Yan Qi2

  • 1Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences (S.-J.P., K.Y.L., S.L.K., F.S.P., P.H.C., K.K.P.), Harvard University, Cambridge, MA.

Circulation
|July 18, 2019
PubMed
まとめ

この研究では,カテコアミナージック多型心室性急性心臓発作 (CPVT) のためのヒト工学心臓組織モデルを開発した. このモデルは,組織レベルでの心律乱を誘発する重要なリン酸化現象を明らかにし,遺伝性心律乱の理解を深めました.

キーワード:
カムキイ心臓発作生物工学カテコアミナージックポリモルフィック心室性タヒカルディアのモデル遺伝子編集幹細胞

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