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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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化学選択ペプチドサイクリングと保護されていないペプチドに直接のサイクリング

Yue Zhang1, Qing Zhang1, Clarence T T Wong2

  • 1Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , P. R. China , SAR.

Journal of the American Chemical Society
|July 18, 2019
PubMed
まとめ

保護されていないペプチドを直接循環させ,アイソインドールブリッジされたサイクルペプチドを形成するために,新しい方法がオルトフェタアルデヒド (OPA) を使用しています. この単純な,水性ベースのアプローチは,サイクルペプチドライブラリ開発のための多様な改変と生物結合を可能にします.

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