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Updated: Jul 13, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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MHCクラスIIの遺伝子発現の規制欠陥を有する先天性免疫不全は,特定のHLA-DRプロモーター結合タンパク質,RF-Xを欠いている

W Reith1, S Satola, C H Sanchez

  • 1Department of Microbiology, University of Geneva Medical School, Switzerland.

Cell
|June 17, 1988
PubMed
まとめ

調節タンパク質であるRF-Xは,MHCクラスIIの遺伝子発現に不可欠である. 欠乏すると,重症複合免疫不全症 (SCID) が起こり,その特徴は,HLAクラスII遺伝子の欠乏であり,免疫調節におけるその重要な役割を強調する.

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